Nelson has a strained right hamstring and groin and is officially listed as "day-to-day" by Magic officials.
E'Twaun Moore, who scored 13 points, grabbed five rebounds and dished out three assists Friday, will start in his place. Ish Smith will handle the backup duties. Smith was scoreless in five minutes Friday.
Gustavo Ayon, who has been out with a thumb injury, is expected to play.