Buehrle gave up two New York home runs, the first to Mets outfielder Jason Bay on a two-run shot in the second inning, and the second to Scott Hairston to lead off the fourth. Buehrle gave up just five hits, but four earned runs. He was pulled for reliever Tom Koehler after the sixth.
Miami made a game of it in the top of the ninth after putting runners in scoring position with no outs, setting up a three-run John Buck home run, but the Marlins would score no more off of Mets reliever Jon Rauch.
The series continues Sunday at 1:10 ET.
For more on the Marlins, visit SB Nation Tampa Bay and Fish Stripes. For more New York Mets, visit SB Nation New York and Amazin' Avenue. And be sure to visit Baseball Nation for all of your Major League Baseball news.