The Jacksonville Jaguars released an updated injury report Friday, and star running back Maurice Jones-Drew is going to sit out the team's game against the Titans on Sunday. This will be the fifth consecutive game that Jones-Drew has missed; he has not played in a game since Oct. 21.

The Jaguars will also be without fullback Greg Jones, who was not able to practice on Friday because of a thigh injury. Defensive back William Middleton has been held out of practice all week because of a concussion and won't play against Tennessee.

Defensive backs Dwight Lowery (ankle) and Rashean Mathis (groin) have been limited in practice all week and are listed as questionable. Lowery has made five starts this season, while Mathis has made four. Both players have missed multiple games due to injury. Center Brad Meester (foot) is probable.

Jacksonville's game against Tennessee is set for a 1 p.m. kickoff on Sunday.