Jacksonville's lone win in 2012 thus far came in Week 3, when the Jaguars, led by Maurice Jones-Drew's 177 rushing yards, defeated the Colts, 22-17. The Jaguars, however, will be without MJD on Thursday, as head coach Mike Mularkey has already ruled the star running back out with a foot injury.
Rashad Jennings will continue to fill in for Jones-Drew.
Indianapolis has been one of the surprise teams in the league this year, and after nine weeks, the Colts find themselves in the middle of the playoff hunt in the AFC. Record-setting rookie quarterback Andrew Luck has been a big part of Indianapolis' success this year, throwing for 2,404 yards through Indianapolis' first eight games, while completing 56.5% of his passes. Luck has thrown 10 touchdowns and has been intercepted eight times.
Per OddsShark, Indianapolis enters the game as 3-point favorites over Jacksonville.
Kickoff is scheduled for 8:20 p.m. ET in Jacksonville. Televised coverage can be found on the NFL Network.