While Tannehill played well, Andrew Luck's Colts came out with the 23-20 victory.
Tannehill, who hyperextended his left knee against the New York Jets last week, completed 22-of-38 passes for 290 yards and a touchdown against the Colts.
The No. 8 overall pick in this year's draft, Tannehill has slowly improved for the Dolphins as the season has progressed. He's completed 59 percent of his passes for 1,762 yards and five touchdowns.
Tannehill also has six interceptions, but he hasn't thrown a pick since a Sept. 30 game against the Arizona Cardinals. He gave up all six interceptions in the first four games of the year.
The Dolphins have also been without cornerback Richard Marshall. Marshall was limited in practice with a back injury, but hasn't played in the team's last four games.