No. 13 Michigan State Spartans at Miami Hurricanes: After beginning the year with a light schedule, the Hurricanes face the first true test of the season when the team plays host to the No. 13 Spartans. After losing in the season opener to Connecticut, the Spartans have won five straight, including a win against Kansas. 7:30 p.m. ET, ESPN

Stetson Hatters at Virginia Commonwealth Rams: The Hatters won each of the first three home games of the year at the Edmunds Center before losing Monday's game against South Florida. A tough challenge awaits with VCU, though, as the Rams will come into the game hungry after back-to-back losses to No. 5 Duke and No. 13 Missouri. 7:30 p.m. ET

Jacksonville Dolphins at South Carolina State Bulldogs: The Dolphins haven't yet been able to string a pair of wins together, losing four of its first six games. However, JU can follow up a win against Milwaukee by handing the Bulldogs a third consecutive defeat. 7:30 p.m. ET

Florida Gulf Coast Eagles at Samford Bulldogs: The Eagles had some tough matchups to begin the season and fared pretty well, even defeating the Miami Hurricanes. Scoring 67 points against Duke is no easy feat either. FGCU has the opportunity to give Samford a sixth consecutive loss on Wednesday night. 8 p.m. ET