Glen Davis had his ninth double-double of the season in the loss.
Orlando cut Utah's 11-point halftime lead to just three, 58-55, with 2:59 remaining in the third but the Jazz finished the quarter on a 10-2 run to extend their lead back to double digits, 68-57, heading into fourth quarter.
Davis finished the game with 18 points and 12 rebounds for his ninth double-double of the season.
After scoring four consecutive points to put the Jazz ahead, 85-81, with 1:29 left in the game, Jefferson left the game after grabbing a defensive rebound with what appeared to be a back injury. Jefferson was taken straight to the locker room and did not return.
The loss snapped Orlando's two-game winning streak and ended Utah's three-game losing streak.