Tampa Bay, which has won three of its last four games, has been carried by the explosion of rookie running back Doug Martin, who has increased his rushing total in each of the last four weeks, culminating in a historic 251-yard effort against the Raiders last week.
San Diego, long one of the most explosive offenses in the NFL, has struggled to move the ball, with quarterback Philip Rivers throwing for 12 touchdowns and 10 interceptions.
If there's a strength for the Chargers, it's up front, as their run defense ranks fourth in the NFL, allowing only 84 yards a game. That could mean a big day for Bucs quarterback Josh Freeman, who has become more effective as he cuts down on his turnovers, throwing for 16 touchdowns and only 5 interceptions so far this season.
The over/under for the game is 48, and as the fine folks at OddsShark point out, the total has gone over in the last five Tampa Bay games and four of the last five San Diego games.