Lewis was the only injury for the Bucs on Sunday. He did not return to the game. Stephen Holder of the Tampa Bay Times said on Twitter that the injury "looks serious":
Just got out of #Bucs locker room. Some updates: CB LeQuan Lewis' knee injury looks serious. No weight on it and using crutches...— Stephen Holder (@HolderStephen) December 3, 2012
Lewis, 23, has been a part-time player for the Bucs this season. Before he left Sunday's game, he had just one tackle -- and it was assisted.
The Bucs picked up Lewis after he was released by the Dallas Cowboys on Oct. 2. He recorded one tackle in three games for the Cowboys.
The Buccaneers are 6-6 this season and fighting for a playoff berth. Tampa Bay will try to go above .500 when it hosts the Philadelphia Eagles on Sunday.