South Florida started the season out 2-0, defeating Chattanooga and Nevada in consecutive weeks. Since then, they have dropped four straight, losing to Rutgers, Ball St., Florida St. and Temple. While South Florida has lost four in a row, they've at least been competitive in the games, losing three games by 10 or fewer points, and only losing by 13 to the then-No. 4 Seminoles.
By contrast, Louisville has yet to lose a game this season, starting out the 2012 season 6-0. Louisville opened the first BCS rankings as the No. 16 team, and are very much alive for a BCS berth come January.
Louisville and South Florida last met in 2011, when the Cardinals defeated the Bulls, 34-24.
The Cardinals head into the game as seven-point favorites, and the over/under has been set at 52.5.
Kickoff is scheduled for 3:30 p.m. ET, from Papa John's Cardinal Stadium in Louisville, Ky. Televised coverage can be found nationally on ABC.