Infante, a second baseman, started his path towards the Major Leagues by signing a free agent contract with the Detroit Tigers in 1999. He initially appeared with the club with a late season call-up in 2002. He hit .333 in 18 games.
Injuries slowed Infante in 2003, his official rookie season. He made the opening day roster, but was limited to 69 games for the Tigers, hitting .222.
Infante continued to play with Detroit through the 2007 season, hitting .254 in 407 games for the Tigers. He was traded to the Chicago Cubs after the season for Jacque Jones, and three weeks later was traded to the Atlanta Braves along with Will Ohman for Jose Ascanio.
Over the next three seasons, Infante appeared in a total of 300 games for the Braves. His batting average was significantly improved over his AL days, as he hit a composite .309 for Atlanta.
Infante was invited to his first All-Star game in 2010 by hitting .321 with eight home runs and 47 RBI. Florida acquired him by trade, also receiving Michael Dunn for first baseman Dan Uggla.
Infante has thus far appeared in 148 games for the Marlins, hitting .276 with 7 home runs and 49 RBI's. His real value lies in his defense, as Infante committed a total of eight errors in 2011, for an excellent .989 fielding percentage.