The team lost running back Rashad Jennings to a concussion during the game. He did not return to the game. Before his exit, Jennings rushed for 20 yards on eight carries.
Jennings is the third starting running back for the Jaguars this year. Maurice Jones-Drew and Jalen Parmele, who went on the injured reserve last week, have also been hurt.
Jacksonville also lost cornerback Aaron Ross, who has a leg injury, and wide receiver Cecil Shorts, who hurt his head. Neither returned to Sunday's game against the Bills.
Ross, 30, has played in 12 games for the Jaguars this season. It is his first year with the Jaguars. Ross has recorded 36 tackles and three pass deflections in nine starts.
Shorts is being treated for a concussion. Before he left, Shorts caught seven passes for 77 yards and a touchdown. He was targeted a game-high 12 times.