Chris Bosh and LeBron James carried the load for Miami with Wade sidelined. Bosh scored 24 points on 9-of-11 shooting and also grabbed nine rebounds. James scored 21 points and pulled down seven boards.
The win was the second in as many games for Miami against Phoenix this season. The Heat are now 8-3 to start the year.
Elsewhere, the Orlando Magic split two weekend games. The Magic snapped a five-game losing streak on Friday by beating the Detroit Pistons 110-106. J.J. Redick's 23 points paced Orlando in the victory.
On Sunday, the Orlando fell 97-86 to the Toronto Raptors. The Magic actually held a two-point lead heading into the fourth quarter, but were then outscored 30-17 in the final frame. Glen Davis' 16 points and 12 rebounds led the Magic, while Jose Calderon had 18 assists for the Raptors.
Orlando is 3-6 on the year.