Linebacker Quincy Black and defensive back Eric Wright each left the game and did not return.
Black, 28, made a helmet-to-helmet tackle on Chargers running back Ryan Mathews. Black had his neck stabilized and was carted off the field. Black is currently having complications in his left arm.
Wright re-aggravated his Achilles injury on Sunday. He's been battling the injury for about two weeks. He is questionable for this week's game against Carolina.
Black is a former third-round draft pick in the 2007 NFL Draft. He's been with the Buccaneers for his entire six-year career, and has been a regular starter for the last four seasons.
Before his injury, Black compiled 25 tackles and two fumble recoveries in nine games. He has 203 tackles and 3 1/2 sacks in his career.
Wright, 27, is in his first season with the Bucs. In nine games this season, Wright has 31 tackles and one interception.